Post Doctoral Scholar
Department of Chemical Engineering
Massachusetts Institute of Technology
77 Massachusetts Avenue, Room: E18-524
Cambridge, MA 02139 USA
Phone: (617) 258-8037
Ph.D. Chemistry, Designated Emphasis in Biotechnology, 2015
University of California, Davis
NSF Graduate Research Fellow
B.A. Biochemistry, Albion College, Michigan, 2009
Harnessing the power of biology to create renewable products for a sustainable future.
Characterization of metabolic perturbations on the performance of genetic circuits in yeast.
Characterization of cellular systems is required for understanding metabolic state and burden that cells endure. Competition for shared resources in genetic circuits can impair cellular functions and limits robustness of developing therapeutic and medicinally relevant synthetic biology tools. I utilize metabolomics analysis, with a focus on bioenergetics and central carbon metabolism.
Combinatorial assembly, screening and functional characterization of a recombinant glucaric acid pathway in S. cerevisiae.
I am optimizing the biosynthetic route to glucaric acid from glucose in S. cerevisiae by screening an intelligently designed set of synthesized constructs containing both a library of promoters and enzyme homologues.
Franz, A. K.; Danielewicz, M. A.; Wong, D. M.; Anderson, L. A.; Boothe, J. R., Phenotypic Screening with Oleaginous Microalgae Reveals Modulators of Lipid Productivity. ACS Chem. Bio. 2013, 8 (5), 1053-1062. 10.1021/cb300573r
Anderson, L. A.; Franz, A. K., Real-Time Monitoring of Transesterification by 1H NMR Spectroscopy: Catalyst Comparison and Improved Calculation for Biodiesel Conversion. Energy Fuels 2012, 26 (10), 6404-6410. 10.1021/ef301035s
Danielewicz, M. A.; Anderson, L. A.; Franz, A. K., Triacylglycerol profiling of marine microalgae by mass spectrometry. J. Lipid Res. 2011, 52 (11), 2101-2108. 10.1194/jlr.D018408
Manpadi, M.; Uglinskii, P. Y.; Rastogi, S. K.; Cotter, K. M.; Wong, Y.-S. C.; Anderson, L. A.; Ortega, A. J.; Van slambrouck, S.; Steelant, W. F. A.; Rogelj, S.; Tongwa, P.; Antipin, M. Y.; Magedov, I. V.; Kornienko, A., Three-component synthesis and anticancer evaluation of polycyclic indenopyridines lead to the discovery of a novel indenoheterocycle with potent apoptosis inducing properties. Org. Biomol. Chem. 2007, 5 (23), 3865-3872. 10.1039/b713820b